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pentobarbital will decrease the extent or effect of parecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.pentobarbital decreases outcomes of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of CYP3A4 inducers might lower sufentanil stages and ef